Epstein-Barr virus transformation of human B lymphocytes despite inhibition of viral polymerase.

نویسندگان

  • J W Sixbey
  • J S Pagano
چکیده

Epstein-Barr virus transformed human lymphocytes despite the presence of up to 500 microM acyclovir [9-(2-hydroxyethoxymethyl)guanine], a viral DNA polymerase inhibitor. The transformed cells contained multiple Epstein-Barr virus genome copy numbers. Functional viral DNA polymerase is probably not required for cell transformation and the initial amplification of the viral genome.

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عنوان ژورنال:
  • Journal of virology

دوره 53 1  شماره 

صفحات  -

تاریخ انتشار 1985